肺脏病学PDF电子书下载

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Part One PERSPECTIVES 1

CHAPTER 1 Milestones in the History of Pulmonary Medicine&Alfred P. Fishman 3

Part Two SCIENTIFIC BASIS OF LUNG FUNCTION IN HEALTH AND DISEASE 19

Section 1 Architecture for Normal Lung FunctionCHAPTER 2 Functional Design of the Human Lung for Gas Exchange&Ewald R.Weibel/C.Richard Taylor 21

CHAPTER 3 The Respiratory Muscles&Marc Decramer 63

CHAPTER 4 Cellular Mechanisms of Lung Development&Jesse Roman 73

CHAPTER 5 Development and Growth of the Lung&Peter H.Burri 91

CHAPTER 6 Cellular and Molecular Mechanisms Regulating Airway Smooth Muscle Physiology and Pharmacology&Reynold A.Panettieri,Jr./Michael I.Kotlikoff 107

CHAPTER 7 Surfactant and Associated Proteins&Jeffrey A.Whitsett/Ann D.Horowitz 119

CHAPTER 8 Transport Function of Airway Epithelia and Submucosal Glands&Paul-B.McCray,Jr./Michael J.Welsh 129

CHAPTER 9 Nonrespiratory Functions of the Lungs&Una S.Ryan/Sarvas C.Makrides 139

Section 2 Physiological Principles of Normal Lung FunctionCHAPTER 10 Pulmonary Mechanics&Murray D.Altose 149

CHAPTER 11 Control of Ventilation&Neil S.Cherniack,Allan I.Pack 163

CHAPTER 12 Ventilation,Pulmonary Blood Flow,and Ventilation-Perfusion Relationships&Peter D.Wagner 177

CHAPTER 13 Diffusion,Chemical Reactions Involving Respiratory Gases,and Diffusing Capacity&Robert A.Klocke 193

CHAPTER 14 Blood-Gas Transport&Michael P.Hlastala,Erik R.Swenson 203

CHAPTER 15 Acid-Base Balance&Stanley Goldfarb,Kumar Sharma 207

Section 3 The Lungs in Different Physiological StatesCHAPTER 16 Exercise,Integration,and Adaptation&Alfred P.Fishman 221

CHAPTER 17 Breathing during Exercise&Brian J.Whipp 229

CHAPTER 18 The Lungs in Pregnancy&John Popovich,Jr. 243

CHAPTER 19 Aging of the Respiratory System&Robert O.Crapo/Edward J.Campbell 251

Section 4 Lung ImmunologyCHAPTER 20 Pulmonary Defense Mechanisms against Infections&Herbert Y.Reynolds/Jack A.Elias 265

CHAPTER 21 Lymphocyte-and Macrophage-Mediated Inflammation in the Lung&Jeffrey S.Berman/David M.Center 275

CHAPTER 22 Mast Cells and Eosinophils&Edward S.Schulnan/Donald G.Raible 289

CHAPTER 23 Antibody-Mediated Lung Defenses and Humoral Immunodeficiency&David N.Weissman/Kenneth S.Landreth/Nevin W.Wilson 303

Section 5 Lung Injury and RepairCHAPTER 24 Cytokines and Chemokines in Lung Inflammation and Injury&Steven L.Kunkel/Robert M.Strieter 315

CHAPTER 25 Leukocyte Accumulation in the Lung&G.Scott Worthen/Jerry A.Nick 325

CHAPTER 26 Nitric Oxide and Lung Injury&Imad Y.Haddad/Bruce R.Pitt/Sadis Matalon 337

CHAPTER 27 The Pathogenesis of Pulmonary Fibrosis&Peter D.Bitterman/Christine H.Wendt 347

Part Three SYMPTOMS AND SIGNS OF RESPIRATORY DISEASE 359

Section 6 Clinical Approach to the PatientCHAPTER 28 Approach to the Patient with Respiratory Symptoms&Alfred P.Fishman 361

CHAPTER 29 Pulmonary Cutaneous Disorders&Brian V.Jegasothy 395

CHAPTER 30 Pulmonary-Systemic Interactions&Alfred P.Fishman 417

Section 7 Diagnostic ProceduresCHAPTER 31 Principles of Effective Care&Peter G.Tuteur 429

CHAPTER 32 Radiographic Evaluation of the Chest Wallace T.Miller 433

CHAPTER 33 Pulmonary Cytopathology&Prabodh K.Gupta 487

CHAPTER 34 Angiographic Techniques in the Evaluation and Management of Suspected Pulmonary Disease&Vincent G.McDermott/Cynthia S.Payne/Tony P.Smith 505

CHAPTER 35 Scintigraphic Evaluation of Pulmonary Disease&Abass Alavi/Daniel Worsley 517

CHAPTER 36 Pulmonary Function Testing&Michael A.Grippi/Louis F.Metzger/Ann V.Sacks/Alfred P.Fishman 533

CHAPTER 37 Principles and Applications of Cardiopulmonary Exercise Testing&Karl T.Weber 575

CHAPTER 38 Bronchoscopy,Transthoracic Needle Aspiration,and Related Procedures&Michael Unger/Daniel H.Sterman 589

CHAPTER 39 Thoracoscopy&Larry R. Kaiser 607

CHAPTER 40 Perioperative Respiratory Considerations in the Surgical Patient&Horace M.DeLisser/Michael A.Grippi 619

CHAPTER 41 Impairment and Disability Evaluation in Lung Disease&Paul E.Epstein 631

Part Four OBSTRUCTIVE LUNG DISEASES 643

Section 8 Chronic Obstructive Pulmonary DiseaseCHAPTER 42 Chronic Obstructive Lung Disease:Overview&Alfred P.Fishman 645

CHAPTER 43 Chronic Obstructive Pulmonary Disease:Epidemiology,Pathophysiology,and Pathogenesis&Robert M.Senior/Steven D.Shapiro 659

CHAPTER 44 Chronic Obstructive Pulmonary Disease:Clinical Course and Management&Ronald B.George/Gerardo S.San Pedro 683

CHAPTER 45 Cigarette Smoking and Disease&Stephen I.Rennard/David M.Daughton 697

CHAPTER 46 Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders&Andrew L.Ries 709

Section 9 AsthmaCHAPTER 47 The Biology of Asthma&William W.Busse/David E.Parry 721

CHAPTER 48 Asthma:Epidemiology&Scott T.Weiss 735

CHAPTER 49 Aspirin-and Exercise-Induced Asthma&Gregory P.Geba 745

CHAPTER 50 Asthma:Clinical Presentation and Management&James E.Fish/Stephen P.Peters 757

CHAPTER 51 Allergic Bronchopulmonary Aspergillosis and Hypersensitivity Reactions to Fungi&Roy Patterson 777

Section 10 Other Obstructive DisordersCHAPTER 52 Upper Airway Obstruction&Sidney S.Braman/Henning A.Gaissert 783

CHAPTER 53 Cystic Fibrosis&Cynthia Robinson/Thomas F.Scanlin 803

CHAPTER 54 Bronchiolitis&Talmadge E.King,Jr. 825

CHAPTER 55 Bullous Diseases of the Lungs&David M.Murphy/Alfred P.Fishman 849

Part Five OCCUPATIONAL AND ENVIRONMENTAL DISORDERS 865

Section 11 Occupational DisordersCHAPTER 56 Occupational Lung Disorders:General Principles and Approaches&Carrie A.Redlich 867

CHAPTER 57 Asbestos-Related Lung Disease&William N.Rom 877

CHAPTER 58 Chronic Beryllium and Hard-Metal Lung Disease&Milton D.Rossman/Jeffrey D.Edelman 893

CHAPTER 59 Coal Workers' Lung Diseases and Silicosis&John E.Parker/Edward L.Petsonk 901

CHAPTER 60 Occupational Asthma,Byssinosis,and Industrial Bronchitis&J.Allen D.Cooper,Jr. 915

CHAPTER 61 Toxic Inhalations&David A.Schwartz/Christine A.Blaski 925

Section 12 Environmental DisordersCHAPTER 62 Indoor and Outdoor Air Pollution&Jonathan M.Samet/Mark J.Utell 941

CHAPTER 63 Pulmonary Adaptation and Clinical Disorders Related to High Altitude&Sukhamay Lahiri/James S.Milledge 965

CHAPTER 64 Diving Injuries and Air Embolism&James M.Clark 979

CHAPTER 65 Thermal Lung Injury and Acute Smoke Inhalation&Jacob S.Loke 989

Part Six DRUG-INDUCED LUNG DISEASES 1001

CHAPTER 66 Pulmonary Toxicity Associated with Chemotherapeutic Agents&Lynn T.Tanoue 1003

CHAPTER 67 Drug-Induced Lung Disease due to Nonchemotherapeutic Agents&Ralph J.Zitnik 1017

Part Seven INTERSTITIAL AND INFLAMMATORY LUNG DISEASES 1035

Section 13 Immunologic and Interstitial DiseasesCHAPTER 68 Interstitial Lung Disease:A Clinical Overview and General Approach&Ganesh Raghu 1037

CHAPTER 69 Systemic Sarcoidosis&David R.Moller 1055

CHAPTER 70 Idiopathic Pulmonary Fibrosis&Joseph P.Lynch Ⅲ/Galen B.Toews 1069

CHAPTER 71 Hypersensitivity Pneumonitis&Mark R.Schuyler 1085

CHAPTER 72 Radiation Pneumonitis&Sara Rockwell/Kenneth B.Roberts 1099

CHAPTER 73 Pulmonary Manifestations of the Collagen Vascular Diseases&Marvin I.Schwarz 1115

CHAPTER 74 The Eosinophilic Pneumonias&Carolyn L.Rochester 1133

Section 14 Depositional and Infiltrative DisordersCHAPTER 75 Depositional Diseases of the Lungs&Richard H.Ochs/Alfred P.Fishman 1151

CHAPTER 76 Pulmonary Histiocytosis X&Talmadge E.King,Jr./Robert S.Crausman 1163

CHAPTER 77 Pulmonary Lymphangioleiomyomatosis&Talmadge E.King,Jr./Robert S.Crausman 1171

CHAPTER 78 The Lungs in Patients with Inborn Errors of Metabolism&Masazumi Adachi 1179

Part Eight ALVEOLAR DISEASES 1191

CHAPTER 79 Alveolar Hemorrhage Syndromes&Joseph P.Lynch Ⅲ/James W.Leatherman 1193

CHAPTER 80 Mechanisms of Aspiration Disorders&Keith M.Robinson/Richard D.Zorowitz 1211

CHAPTER 81 Pulmonary Alveolar Proteinosis&Anders Persson 1225

Part Nine DISORDERS OF THE PULMONARY CIRCULATION 1231

CHAPTER 82 The Pulmonary Circulation&Alfred P.Fishman 1233

CHAPTER 83 Pulmonary Hypertension and Cor Pulmonale&Alfred P.Fishman 1261

CHAPTER 84 Pulmonary Thromboembolic Disease&Harold I.Palevsky/Mark A.Kelley/Alfred P.Fishman 1297

CHAPTER 85 Pulmonary Edema&Daniel P.Schuster 1331

CHAPTER 86 Pulmonary Vasculitis&Richard A. DeRemee 1357

CHAPTER 87 Pulmonary Arteriovenous Malformations&Daniel M.Goodenberger 1375

Part Ten DISORDERS OF THE PLEURAL SPACE 1387

CHAPTER 88 Pleural Fluid Dynamics and Effusions&Gary T.Kinasewitz 1389

CHAPTER 89 Nonmalignant Pleural Effusions&Richard H.Winterbauer 1411

CHAPTER 90 Malignant Pleural Effusions&Steven A.Sahn 1429

CHAPTER 91 Pneumothorax&Jay I.Peters/Edward Y.Sako 1439

CHAPTER 92 Malignant Mesothelioma and Other Primary Pleural Tumors&Steven M.Albelda/Daniel H.Sterman/Leslie A.Litzky 1453

Part Eleven DISEASES OF THE MEDIASTINUM 1467

CHAPTER 93 The Mediastinum:Overview,Anatomy,and Diagnostic Approach&Joe B.Putnam,Jr. 1469

CHAPTER 94 Nonneoplastic Disorders of the Mediastinum&Cameron D.Wright 1485

CHAPTER 95 Congenital Cysts of the Mediastinum:Bronchopulmonary Foregut Anomalies&Malcolm M.DeCamp,Jr. 1499

CHAPTER 96 Acquired Lesions of the Mediastinum:Benign and Malignant&John R.Roberts/Larry R.Kaiser 1509

Part Twelve DISORDERS OF THE CHEST WALL,DIAPHRAGM,AND SPINE 1539

CHAPTER 97 Nonmuscular Diseases of the Chest Wall&F.Dennis McCool/Dudley F.Rochester 1541

CHAPTER 98 Effects of Neuromuscular Diseases on Ventilation&Gerard Joseph Criner/Steven G.Kelsen 1561

CHAPTER 99 Pulmonary Rehabilitation in Neuromuscular Diseases&John R.Bach 1587

Part Thirteen SLEEP AND SLEEP DISORDERS 1597

CHAPTER 100 The Stages of Sleep&Adrian R.Morrison 1599

CHAPTER 101 Changes in the Cardiorespiratory System during Sleep&Allan I.Pack/Leszek Kubin/Richard O.Davies 1607

CHAPTER 102 Sleep Apnea Syndromes&Richard J.Schwab/Andrew N.Goldberg/Allan I.Pack 1617

CHAPTER 103 Differential Diagnosis and Evaluation of Sleepiness&Meir H.Kryger/Charles F.P.George 1639

Part Fourteen SURGICAL ASPECTS OF PULMONARY MEDICINE 1647

CHAPTER 104 Perioperative Care of the Patient Undergoing Lung Resection&Robert J.Downey 1649

CHAPTER 105 Thoracic Trauma&Larry R.Kaiser/Francis W.DiPierro 1661

CHAPTER 106 Lung Transplantation&John C.Wain 1671

Part Fifteen NEOPLASMS OF THE LUNGS 1693

Section 15 Cancer of the LungsCHAPTER 107 Genetic and Molecular Changes of Human Lung Cancer&Jeffrey A.Kern/Geoffrey McLennan 1695

CHAPTER 108 Epidemiology of Lung Cancer&Pieter E.Postmus 1707

CHAPTER 109 Cigarette Smoking and Health Policy&Alfred P.Fishman 1719

CHAPTER 110 The Solitary Pulmonary Nodule:A Systemic Approach&Alan M.Fein/Steven H.Feinsilver/Carlos A.Ares 1727

CHAPTER 111 The Pathology of Non-Small Cell Lung Carcinoma&Leslie A.Litzky 1739

CHAPTER 112 Non-Small Cell Lung Cancer-Clinical Aspects,Diagnosis,Staging,and Natural History&Mitchell L.Margolis 1759

CHAPTER 113 Part Ⅰ:Treatment of Non-Small Cell Lung Cancer:Surgical&Larry R.Kaiser 1783

Part Ⅱ：Treatment of Non-Small Cell Lung Cancer:Chemotherapy&Joseph Treat 1797

Part Ⅲ: Treatment of Non-Small Cell Lung Cancer:Radiation Therapy&William T.Sause/Mitchell Machtay 1805

CHAPTER 114 Small Cell Lung Cancer:Diagnosis,Treatment,and Natural History&David H.Johnson/Charles D.Blanke 1819

CHAPTER 115 Primary Lung Tumors Other Than Bronchogenic Carcinoma:Benign and Malignant&Steven M.Keller/Kushagra Katariya 1833

CHAPTER 116 Extrapulmonary Syndromes Associated with Lung Tumors&Bruce E.Johnson/John P.Chute 1841

CHAPTER 117 Pulmonary Metastases&Michael E.Burt 1851

Section 16 Lymphoproliferative DisordersCHAPTER 118 Lymphoproliferative and Hematologic Diseases Involving the Lung&Guiseppe G.Pietra/Kevin E.Salhany 1861

Part Sixteen INFECTIOUS DISEASES OF THE LUNGS 1881

Section 17 General IssuesCHAPTER 119 Microbial Flora and Colonization of the Respiratory Tract&Waldemar G.Johanson,Jr./Lisa L.Dever 1883

CHAPTER 120 Pulmonary Clearance of Infectious Agents&Galen B.Toews 1891

CHAPTER 121 Approach to the Patient with Pulmonary Infections&Morton N.Swartz 1905

CHAPTER 122 Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia&Michael S.Niederman 1939

CHAPTER 123 Local Therapy and Pharmacokinetics of Antibiotics in the Lungs&Jean A. Klastersky/Mickael Aoun 1951

CHAPTER 124 Vaccination for Pulmonary Infections&Michael S.Simberkoff 1959

CHAPTER 125 Microbial Virulence Factors in Pulmonary Infections&James L.Michel/Gerald B.Pier 1967

Section 18 Pulmonary Infectious SyndromesCHAPTER 126 Infections of the Upper Respiratory Tract&Marlene Durand/Saumil N.Merchant/Ann Sullivan Baker 1973

CHAPTER 127 Acute Bronchitis and Community-Acquired Pneumonia&Thomas J.Marrie 1985

CHAPTER 128 Pneumonia in Childhood&Mark S.Pasternack 1997

CHAPTER 129 Aspiration Disease and Anaerobic Infection&John G.Bartlett 2011

CHAPTER 130 Empyema and Lung Abscess&Sydney M.Finegold/Jay A.Fishman 2021

CHAPTER 131 Mediastinitis&Mark E.Rupp 2035

CHAPTER 132 Bronchiectasis&Morton N.Swartz 2045

CHAPTER 133 Systemic Infection,the Sepsis Syndrome,and the Lungs&Richard Teplick/Jay A.Fishman 2071

Section 19 Special Hosts and Opportunistic InfectionsCHAPTER 134 Introduction:Pulmonary Infection in Special Hosts&Jay A.Fishman 2095

CHAPTER 135 HIV Infection and Opportunistic Pulmonary Infections in AIDS&Jay A.Fishman 2103

CHAPTER 136 Pulmonary Infections in Neutropenia and Cancer&Jay A.Fishman 2121

CHAPTER 137 Respiratory Disease in Bone Marrow and Hematopoietic Stem Cell Transplantation&Stephen W.Crawford 2137

CHAPTER 138 Pneumonia in the Organ Transplant Patient&Jay A.Fishman/Robert H.Rubin 2153

CHAPTER 139 Pulmonary Infections in Patients with Primary Immune Defects&Harry R.Hill/Kathleen D.Pfeffer 2165

CHAPTER 140 Postoperative Pneumonia&Ronald Lee Nichols/William D.Hardin,Jr. 2179

CHAPTER 141 Respiratory Infections in the Economically Disadvantaged&Edward A.Nardell/David Kent 2187

Section 20 Specific MicroorganismsCHAPTER 142 Pneumonias Caused by Gram-Positive Bacteria&Alan L.Bisno/Gordon M.Dickinson/David S.McKinsey 2199

CHAPTER 143 Nosocomial Respiratory Tract Infections and Gram-Negative Pneumonia&David J.Weber/William A.Rutala/C.Glen Mayhall 2213

CHAPTER 144 Legionellosis&Victor L.Yu/Emanuel N.Vergis 2235

CHAPTER 145 Mycoplasma,Chlamydia,and "Atypical Pneumonias"&Maurice A.Mufson 2247

CHAPTER 146 Actinomycosis and Nocardiosis&Gregory A.Filice/Donald Armstrong 2257

CHAPTER 147 Aspergillus Syndromes,Mucormycosis,and Pulmonary Candidiasis&Alan M.Sugar/Elizabeth A.Olek 2265

CHAPTER 148 Endemic Mycoses of North America:Histoplasmosis,Coccidioidomycosis,and Blastomycosis&L.Joseph Wheat 2289

CHAPTER 149 Cryptococcal Infections&Mitchell M.Goldman/L.Joseph Wheat 2305

CHAPTER 150 Prteumocystis Carinii&Jay Alan Fishman 2313

CHAPTER 151 Viral Infections of the Lung and Respiratory Tract&Stephen B.Greenberg 2333

CHAPTER 152 The Lung in Human Immunodeficiency Virus Infection&Elizabeth A.Rich 2347

CHAPTER 153 Emerging Infectious Diseases and Hantavirus Pulmonary Syndrome&Jay C.Butler/Sherif R.Zaki 2357

CHAPTER 154 Poliovirus and Other Enterovirus Infections&Joseph L.Melnick 2367

CHAPTER 155 Protozoan Infections of the Thorax&Jeffrey K.Griffiths/David J.Wyler 2379

CHAPTER 156 Helminthic Diseases of the Lungs&Adel A.F.Mahmoud 2401

CHAPTER 157 Zoonotic and Other Unusual Bacterial Pneumonias&Arnold N.Weinberg/Howard M.Heller 2413

Section 21 Mycobacterial InfectionsCHAPTER 158 The Epidemiology,Transmission,and Prevention of Tuberculosis in the United States&Ida M.Onorato/Renée Ridzon 2431

CHAPTER 159 The Microbiology of the Mycobacteria&Frits van der Kuyp 2441

CHAPTER 160 Pathogenesis of Pulmonary Tuberculosis&Arthur M.Dannenberg,Jr./Joseph F.Tomashefski,Jr. 2447

CHAPTER 161 Screening for Tuberculosis and Tuberculosis Infection in High-Risk Populations&Alan B.Bloch 2473

CHAPTER 162

Clinical Presentation and Treatment of Tuberculosis&Milton D.Rossman/A.Fuson Oner-Eyuboglu 2483

CHAPTER 163 Mycobacterial Infections and HIV Infection&Richard E.Chaisson 2503

CHAPTER 164 Diseases due to Mycobacteria Other than Mycobacterium Tuberculosis&Paul T.Davidson 2513

Part Seventeen ACUTE RESPIRATORY FAILURE 2523

Section 22 Lung FailureCHAPTER 165 Respiratory Failure:An Overview&Michael A.Grippi 2525

CHAPTER 166

Acute Respiratory Distress Syndrome: Pathogenesis&Jean E.Rinaldo/John W.Christman 2537

CHAPTER 167

Acute Respiratory Distress Syndrome:Clinical Features,Management,and Outcome&Leonard D.Hudson/Kenneth P.Steinberg 2549

CHAPTER 168 The Systemic Inflammatory Response Syndrome and the Multiple Organ Dysfunction Syndrome&Clifford S.Deutschman 2567

CHAPTER 169 Respiratory Distress Syndrome in Premature Newborn Infants&Walker A.Long/Anthony Corbet 2575

CHAPTER 170 Acute Respiratory Failure in the Surgical Patient&Robert M.Kotloff 2589

Section 23 Respiratory Pump FailureCHAPTER 171

Pump Failure:The Pathogenesis of Hypercapnic Respiratory Failure in Patients with Lung and Chest Wall Disease&Steven G.Kelsen/Gerard Joseph Criner 2605

Section 24 Management and Therapeutic InterventionsCHAPTER 172 Oxygen Therapy and Pulmonary Oxygen Toxicity&Michael F.Beers 2627

CHAPTER 173 Pulmonary Pharmacotherapy&Scott Manaker/Karen J.Tietze/Eric T.Wittbrodt 2643

CHAPTER 174 Intubation and Upper Airway Management&C.William Hanson Ⅲ 2661

CHAPTER 175 Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure&Jonathan Gottlieb 2673

CHAPTER 176 Mechanical Ventilation:Conventional Modes and Settings&Martin J.Tobin 2691

CHAPTER 177 Mechanical Ventilation: Physiological Considerations and New Ventilatory Techniques&John J.Marini 2709

CHAPTER 178 Nutrition in Acute Respiratory Failure&Susan K.Pingleton 2727

CHAPTER 179 Treatment of Agitation and Distress in Mechanically Ventilated Patients&John Hansen-Flaschen 2739

CHAPTER 180 Decision Making in the Intensive Care Unit&Mark A.Kelley 2753

CHAPTER 181 Ethics in the Intensive Care Unit&Paul N.Lanken 2761

CHAPTER 182 Prevention and Control of Lung Disease&Suzanne S.Hurd/Claude Lenfant 2773

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