药理学实验教程 英汉双语版PDF电子书下载

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Chapter 1 General knowledge of animal experiments 1

Section 1 Ethics and protection of experimental animals 1

Section 2 General knowledge of animal experiments 2

Section 3 Introduction of common surgical instruments 8

Section 4 Writing format and requirements of laboratory report 10

Chapter 2 Experiments of pharmacological general principles 11

Section 1 Determination of dose-response relationship of drug 11

Section 2 Measurement of LD50 13

Section 3 Determination pA2 of diphenhydramine 15

Section 4 Body distribution of ibuprofen 17

Section 5 Determination of the serum concentration and pharmacokinetics of phenolsulfonphthalein 20

Section 6 Measurement of half-life time of drug 22

Section 7 Effects of liver function on drug action 24

Section 8 The effects of different routes of administration on drug action 26

Chapter 3 Experiments of autonomic nervous system 29

Section 1 Effects of drugs on eye pupils 29

Section 2 Effects of drugs on isolated intestinal smooth muscle 31

Section 3 Poisoning of organophosphates and rescue 32

Section 4 Effects of drugs on isolated aorta ring 34

Section 5 Effects of drugs on blood pressure in anesthetized animals 36

Section 6 Effects of drugs on hemodynamics in anesthetized animals 38

Chapter 4 Experiments of central nervous system 41

Section 1 Sedative-hypnotic effects of diazepam 41

Experiment 1 Effects of diazepam on spontaneous activity 41

Experiment 2 Hypnotic effects of diazepam 42

Section 2 Influence of enzyme inducer and inhibitor on pentobarbital-induced hypnotic effects 43

Section 3 Anticonvulsant effect of phenobarbital 45

Experiment 1 Maximal electroshock test 45

Experiment 2 Chemical-induced convulsion 47

Section 4 Analgesic effect of drugs 48

Experiment 1 Analgesic effect of aspirin by writhing test 48

Experiment 2 Analgesic effect of pethidine by hot plate test 50

Section 5 Effects of chlorpromazine on body temperature regulation 51

Section 6 Conduction anesthetic effect of procaine 52

Section 7 Comparison of anesthetic effect and toxicity of local anesthetics 54

Experiment 1 Local anesthetic action of procaine 54

Experiment 2 Comparison of toxicity of local anesthetics 55

Section 8 Effects of vasoconstrictor and vasodilator on local anesthesia duration 57

Chapter 5 Experiments of cardiovascular system 59

Section 1 Effects of ions and drugs on isolated heart 59

Section 2 Anti-arrhythmic effects of drugs 61

Experiment 1 Effects of lidocaine on BaCl2 induced arrhythmias 61

Experiment 2 Effects of quinidine on aconitine induced arrhythmias 63

Experiment 3 Effect of propranolol on adrenaline induced tachycardia 65

Section 3 Effects of cardiac glycosides on failed heart 66

Section 4 Effects of drugs on acute ischemic ECG appearance induced by pituitrin 68

Section 5 Anti-hypoxia effects of anti-anginal drugs 70

Chapter 6 Experiments of internal organs system 72

Section 1 Anti-coagulant effect of heparin 72

Section 2 Effects of furosemide on urine volume and electrolytes 73

Section 3 Effects of drugs on asthma stimulated by histamine 75

Section 4 Effects of chlorphenamine on histamine increased capillary permeability 77

Section 5 Effects of drugs on bile secretion 79

Chapter 7 Experiments of endocrine system 81

Section 1 Anti-inflammatory effects of glucocorticoids 81

Section 2 Effects of insulin and oral anti-diabetes drugs on blood glucose levels 82

Section 3 Hypoglycemic response to insulin overdose and rescue 84

Section 4 Effects of indomethacin on gout attack 85

Section 5 Effects of drugs on isolated uterine contraction 87

Chapter 8 Medical experiment research training 90

Section 1 Basic knowledge and skills of medical literature retrieval 90

Section 2 Selection of topics 94

Section 3 Experimental design 98

Section 4 Implementation of experimental research 104

Section 5 Writing of research paper 107

Appendix 111

Appendix 1 Physiological parameters of commonly used laboratory animals 111

Appendix 2 Preparation of common physiological solutions 111

Appendix 3 Dosage conversion of different experimental animals 112

Index of English-Chinese terms 113

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